Psychological horror involving being mostly aware as your memories are warped and destroyed, repeating the history you're doomed to forget, and creepy people taking advantage of others' amnesia.

Clementine and Joel's relationship is shown in all its messy, decaying glory, and it's not pretty to watch: Clem drives drunk in Joel's car and calls him a faggot, he accuses her of fucking around because that's the only way she knows how to get close to people, and so on. Your mileage may vary as to whether you think their relationship CAN recover. Also infidelity and medical/scientific negligence.